About the synthesis process of pyridine

About the synthesis process of pyridine

Pyridine can be obtained from natural coal tar or from acetaldehyde and ammonia. Pyridine and its derivatives can also be synthesized by a variety of methods, the most widely used of which is the synthesis of Hanchipyridine, which uses two molecules of β-carbonyl compounds, such as ethyl acetoacetate, to condense with one molecule of acetaldehyde. Condensation with a molecule of ethyl acetoacetate and ammonia to form a dihydropyridine compound, followed by dehydrogenation with an oxidizing agent such as nitrous acid, followed by hydrolysis of the decarboxylated pyridine derivative. It can also be prepared by passing a catalyst at 500 ° C with acetylene, ammonia and methanol.

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